How might the regeneration process in salamanders and planarians differ

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Q&A: What is regeneration, and why look to planarians for answers?

how might the regeneration process in salamanders and planarians differ

what can organisms that can completely regenerate do. asexual reproduction. What can regenerate body parts. salamanders. T or F there is a tradeoff between .


In biology , regeneration is the process of renewal, restoration, and growth that makes genomes , cells , organisms , and ecosystems resilient to natural fluctuations or events that cause disturbance or damage. Above the genetic level, regeneration is fundamentally regulated by asexual cellular processes. For example, hydra perform regeneration but reproduce by the method of budding. The hydra and the planarian flatworm have long served as model organisms for their highly adaptive regenerative capabilities. Echinoderms such as the sea star , crayfish, many reptiles, and amphibians exhibit remarkable examples of tissue regeneration. The case of autotomy , for example, serves as a defensive function as the animal detaches a limb or tail to avoid capture.

Regeneration requires signaling from a wound site for detection of the wound, and a mechanism that determines the nature of the injury to specify the appropriate regenerative response. Wound signals and tissue responses to wounds that elicit regeneration remain poorly understood. Planarians are able to regenerate from essentially any type of injury and present a novel system for the study of wound responses in regeneration initiation. Newly developed molecular and cellular tools now enable study of regeneration initiation using the planarian Schmidtea mediterranea. Planarian regeneration requires adult stem cells called neoblasts and amputation triggers two peaks in neoblast mitoses early in regeneration. We demonstrate that the first mitotic peak is a body-wide response to any injury and that a second, local, neoblast response is induced only when injury results in missing tissue. This second response was characterized by recruitment of neoblasts to wounds, even in areas that lack neoblasts in the intact animal.

So what can we learn from these regenerative animals? Salamanders, planarians and a number of other species regrow damaged or missing body parts. This is regeneration. Regeneration can happen in many different ways using pluripotent or tissue-specific stem cells. Some regeneration happens without stem cells at all e.

Planarian regeneration involves distinct stem cell responses to wounds and tissue absence

Regeneration (biology)

Historically, philosophers, naturalists and biologists alike have referred to the restoration of missing body parts after traumatic injury as regeneration. While still valid today, the concept of regeneration has expanded through the years to include a diverse set of phenomena. For instance, August Weisman considered physiological cell renewal to be regeneration and wrote so in a chapter dedicated to regeneration in his seminal book The Germ Plasm : 'the functions of certain organs depend on the fact that their parts continually undergo destruction, and are then correspondingly renewed. In this case it is the process of life itself, and not an external enemy, that destroys the life of a cell' [ 1 ]. Soon after, TH Morgan would also attempt to refine the precision of the concept of regeneration by coining terms that distinguish between regeneration requiring cell proliferation epimorphosis and regeneration effected by tissue remodeling morphallaxis [ 2 ]. Presently, regeneration is used to include multiple restorative processes manifested either as a result of physiological turnover for example, the renewal of blood, skin and gut epithelial cells or injury, and more recently has been used to define a branch of medical practice referred to as 'regenerative medicine'. Thus, rather than becoming more specific, the concept of regeneration has become much more general.

Post a Comment. Regenerating complex tissues is an enviable ability. The remarkable ability to regenerate body parts is fairly common amongst invertebrates. If you chop up a flat worm planarian in several bits, they will each grow into a tiny worm scientists have even been able to grow flat worms from single cells! When spiders and some insects amputate their own limbs because of an injury or as a defence against predators, a new limb identical to the original one will grow back. In vertebrates, this kind of regeneration is unique to salamanders, and to some extent to fish and frog tadpoles but not adults.



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  1. Q&A: What is regeneration, and why look to planarians for answers? | BMC Biology | Full Text

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